What is Setipiprant?

What is Setipiprant?

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The emotional toll of dealing with hair loss can be devastating for some, and surely they may do research and expect solutions from drugs such as Setipiprant. Hair loss does not only affect psychological well-being but also may hurt the physical health as well. Sometimes the treatments which are used for dealing with hair loss are a never-ending cycle of failure and disappointment. The commonality of baldness or thinning hair does not lessen the anxiety of the sufferer. Hair has always been a sign of beauty and denotes different things for different people.

Globally, around 60% of males and 50% of females experience hair loss in some way. This is why many people try to revitalize the health of their scalp using different remedies. It may involve the use of oils, some shampoos or lotions, or medicines. They all are temporary measures and can’t help with excessive hair loss. The good news is that the history of transplantation surgery dates back to the late 1930s. For long, research has been done in the area to improve techniques and results. And the verdict remains that hair transplant surgery offers a permanent solution to the problem of hair loss.

The Search for Alternative Ways

Although hair transplant is the best way to solve hair loss problem, many are working on alternative treatments. Drug companies are looking to make a breakthrough and offer a cure to hair loss without any need for surgery. And the claims on the effectiveness of many shampoos and lotions for treating hair loss continue to be heard.

The important thing to remember when trying out any treatment is not to let go of hope. There are always ways in which the problem of hair fall can be solved for the long-term. These days even the ordinary shampoo products we buy from the markets claim to “strengthen the hair” and “fight hair loss.” For some, it might work, but for the others, all they end up seeing is a differently coloured bottle providing the same results over and over again. Then you should understand that the problem lies elsewhere, and you’re not currently solving it.

There is something that has gone on to attract quite some attention and fame other than hair transplant surgery. It is called Setipiprant, and in this article, we want to demystify all the mystery and questions that surround it. So, let’s get into it.

What is this Setipiprant?

Setipiprant is an investigational drug. By now, it must be clear what it’s used for – to prevent hair loss. It has come forth like a ray of hope for those looking for treatment, and many believe that this medicine can help them.

The drug, however, is still in the developmental stages and is being seen as a potential treatment for those suffering from excessive hair fall. More specifically, it aims to fight against androgenetic alopecia in males. A rather problematic thing though is that the effectiveness of the drug has not been proven yet.  Therefore we can’t say for sure whether it works or not. This is the reason why we think it is better to have a hair transplant since it provides permanent and natural results with a high success rate. Of course, sometimes people don’t require surgery for their problem. For them, we make sure to provide alternative solutions in our consultation.

What is Androgenetic Alopecia?

A common reason why thousands come to Turkey is hair transplant surgery. The reason for hair loss among many patients, while there may be other causes, is usually male or female-pattern baldness. The medical term ascribed to the condition is known as androgenetic alopecia. This is a hereditary problem in which hair is lost gradually over time and often formulates predictable patterns. This results due to the diminishing of the hair growth cycle. As the hair continues to become weak and thin, you can start seeing a noticeable change in the overall volume of your hair.

The reason for its occurrence is the male sex hormones known as androgens. They are responsible for, among other things, development of secondary sexual characteristics in males, including deepening of the voice and the formation of facial and body hair.

According to the U.S. National Library of Medicine, more than half males over the age of 50 will experience male pattern baldness to a certain extent. And by the age of 60, every two out of three men will suffer from this. It is seen as receding hairline in males and thinning hair in females. Although it is not necessary that people start to suffer from pattern baldness at the ages mentioned above because genetics can play a role in determining that too. 

The drug – Setipiprant – aims to find a cure for hair loss caused as a result of androgenetic alopecia in males. The question, however, remains that does the medicine work or is it just another thing that would fade away into oblivion? 

The Relation between Setipiprant and Hair Loss

As described above, Setipiprant is an investigational drug, and its effects have not yet been proven. Currently, a study is being conducted with 169 people in the sample for a couple of years. It aims to evaluate the safety, tolerability, and efficacy of Setipiprant tablets of 1000 mg twice a day (BID/ bis in die meaning two times in one day) relative to placebo in 18 to 49 years old males with androgenetic alopecia (AGA).  

How does it work? 

Basically, Setipiprant is an antagonist of the prostaglandin (a hormone-like substance). It has been linked to various pathological responses, including those in allergies, asthma, and inflammation.  

History of Drug Development

It all started back in 2012 when for the first time research found out that there existed a link between the prostaglandin D2 receptor (PGD2) and the loss of hair. As it is with scientific research and development of knowledge, the work was important and worth it so, it continued. What interesting was that those men whose scalps were diagnosed with androgenetic alopecia (AGA) had a higher concentration of the said receptor in them.  

Androgenetic alopecia or male-pattern baldness is the commonest cause of hair loss in men. While the symptoms may start developing at an early age (teen years), ageing worsens them. In the United States alone, 50 million men suffer from AGA.

Cause of Androgenetic Alopecia 

The reason cited for the development of AGA is sensitivity to the hormone DHT, which is an androgen sex steroid produced as a by-product of the hormone testosterone. The DHT contributes to hair loss by attaching or binding itself to the hair follicles, which leads to inflammation and irritation. As a result, the hair follicles become weak, and the hair starts to grow thin until it eventually stops growing completely.

How far along is the Study? 

Currently, the trails are still ongoing. However, the drug has entered in Phase II out of the total 4 of them. The completion of the study and presentation of concrete results will take quite a few years and, meanwhile, there are no assurances whether any side effects of the drug will be found or not. 

Moreover, we’re also not sure what the data will indicate about the efficiency of the drug and the period for which its effectiveness will last. It will only go for FDA approval once the research has been completed successfully. If not, then it will soon become a thing of the past. 

Is Hair Transplant the Better Option? 

Well, we certainly think so. It is because the results of hair transplant usually last for a lifetime. Healthy follicles from the donor area, which show strong growth, are transplanted. They will grow naturally like the rest of your hair. 

Sometimes people get concerned about a condition that occurs temporarily known as shock loss. It is only the result of the trauma of surgery on the scalp and does not indicate, in any way, the failure of hair transplant surgery. Your hair will grow back as strong as ever, and if you’ve followed our instructions and post-op guidelines completely, then you’ve got nothing to be afraid of.

Concluding Remarks 

Hair transplant is a treatment for hair loss that has years and years of backing. It seems to be a better option since it has been performed for quite a long time. All along it has been providing patients with natural-looking and permanent results. 

If you too are suffering from androgenetic alopecia, then it’s better to look for a solution that has been proven for its effectiveness. How Setipiprant will turn out is yet to be determined as the drug is still in the second phase of trials.

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